EHNA hydrochloride

Research use only, not for human use.

EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner.

EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.

EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity.EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity.EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.

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Microbiology/Virology

Influenza Virus

Adenosine deaminase | Influenza Virus | PDE

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58337-38-5

313.83

C14H24ClN5O

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (318.64 mM; Ultrasonic) DMSO : 83.33 mg/mL (265.53 mM; Ultrasonic (<60°C)

[C@H](CCCCCC)([C@@H](C)O)N1C=2C(N=C1)=C(N)N=CN2.Cl

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(-20℃)

With Ice Pack

≥ 2 years